α‐Synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects
Identifieur interne : 001158 ( Main/Exploration ); précédent : 001157; suivant : 001159α‐Synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects
Auteurs : A. Bloch [Suisse] ; A. Probst [Suisse] ; H. Bissig [Suisse] ; H. Adams [Suisse] ; M. Tolnay [Suisse]Source :
- Neuropathology and Applied Neurobiology [ 0305-1846 ] ; 2006-06.
English descriptors
- KwdEn :
Abstract
Studies on cases with incidental Lewy body disease (ILBD) suggest that α‐synuclein (αSN) pathology of Parkinson's disease (PD) starts in lower brainstem nuclei and in the olfactory bulb. However, medullary structures as the induction site of αSN pathology have been questioned as large parts of the nervous system, including the spinal cord and the peripheral autonomic nervous system (PANS), have not been examined in ILBD. Thus, the time course of PD lesions in the spinal cord or PANS in relation to medullary lesions remains unknown. We collected 98 post mortem cases with no reference to PD‐associated symptoms on clinical records. αSN pathology was found in the central nervous system, including the spinal cord, and in the PANS in 17 (17.3%) cases. αSN pathology was encountered in autonomic nuclei of the thoracic spinal cord, brainstem and olfactory nerves in 17/17, in sacral parasympathetic nuclei in 15/16, in the myenteric plexus of oesophagus in 14/17, in sympathetic ganglia in 14/17, and in the vagus nerve in 12/16 cases. In addition to the thoracic lateral horns, a high number of αSN lesions was also found in non‐autonomic spinal cord nuclei. Considering supraspinal structures our cases corresponded roughly to the recently described sequential order of αSN involvement in PD. Our study indicates, however, that the autonomic nuclei of the spinal cord and the PANS belong to the most constantly and earliest affected regions next to medullary structures and the olfactory nerves. A larger cohort of ILBD cases will be needed to pinpoint the precise induction site of αSN pathology among these structures.
Url:
DOI: 10.1111/j.1365-2990.2006.00727.x
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">α‐Synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects</title><author><name sortKey="Bloch, A" sort="Bloch, A" uniqKey="Bloch A" first="A." last="Bloch">A. Bloch</name></author><author><name sortKey="Probst, A" sort="Probst, A" uniqKey="Probst A" first="A." last="Probst">A. Probst</name></author><author><name sortKey="Bissig, H" sort="Bissig, H" uniqKey="Bissig H" first="H." last="Bissig">H. Bissig</name></author><author><name sortKey="Adams, H" sort="Adams, H" uniqKey="Adams H" first="H." last="Adams">H. Adams</name></author><author><name sortKey="Tolnay, M" sort="Tolnay, M" uniqKey="Tolnay M" first="M." last="Tolnay">M. Tolnay</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:723ADF43379CF2E95E18D5B6A936512CAF5E10F6</idno><date when="2006" year="2006">2006</date><idno type="doi">10.1111/j.1365-2990.2006.00727.x</idno><idno type="url">https://api.istex.fr/document/723ADF43379CF2E95E18D5B6A936512CAF5E10F6/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000915</idno><idno type="wicri:Area/Main/Curation">000796</idno><idno type="wicri:Area/Main/Exploration">001158</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">α‐Synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects</title><author><name sortKey="Bloch, A" sort="Bloch, A" uniqKey="Bloch A" first="A." last="Bloch">A. Bloch</name><affiliation wicri:level="1"><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Pathology, Department of Neuropathology, University Hospital Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Probst, A" sort="Probst, A" uniqKey="Probst A" first="A." last="Probst">A. Probst</name><affiliation wicri:level="1"><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Pathology, Department of Neuropathology, University Hospital Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Bissig, H" sort="Bissig, H" uniqKey="Bissig H" first="H." last="Bissig">H. Bissig</name><affiliation wicri:level="1"><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Pathology, Department of Neuropathology, University Hospital Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Adams, H" sort="Adams, H" uniqKey="Adams H" first="H." last="Adams">H. Adams</name><affiliation wicri:level="1"><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Pathology, Department of Neuropathology, University Hospital Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Tolnay, M" sort="Tolnay, M" uniqKey="Tolnay M" first="M." last="Tolnay">M. Tolnay</name><affiliation wicri:level="1"><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Pathology, Department of Neuropathology, University Hospital Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Neuropathology and Applied Neurobiology</title><idno type="ISSN">0305-1846</idno><idno type="eISSN">1365-2990</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2006-06">2006-06</date><biblScope unit="volume">32</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="284">284</biblScope><biblScope unit="page" to="295">295</biblScope></imprint><idno type="ISSN">0305-1846</idno></series><idno type="istex">723ADF43379CF2E95E18D5B6A936512CAF5E10F6</idno><idno type="DOI">10.1111/j.1365-2990.2006.00727.x</idno><idno type="ArticleID">NAN727</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0305-1846</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Lewy bodies</term><term>Lewy neurites</term><term>Parkinson's disease</term><term>autonomic nervous system</term><term>incidental Lewy body disease</term><term>α‐synuclein</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Studies on cases with incidental Lewy body disease (ILBD) suggest that α‐synuclein (αSN) pathology of Parkinson's disease (PD) starts in lower brainstem nuclei and in the olfactory bulb. However, medullary structures as the induction site of αSN pathology have been questioned as large parts of the nervous system, including the spinal cord and the peripheral autonomic nervous system (PANS), have not been examined in ILBD. Thus, the time course of PD lesions in the spinal cord or PANS in relation to medullary lesions remains unknown. We collected 98 post mortem cases with no reference to PD‐associated symptoms on clinical records. αSN pathology was found in the central nervous system, including the spinal cord, and in the PANS in 17 (17.3%) cases. αSN pathology was encountered in autonomic nuclei of the thoracic spinal cord, brainstem and olfactory nerves in 17/17, in sacral parasympathetic nuclei in 15/16, in the myenteric plexus of oesophagus in 14/17, in sympathetic ganglia in 14/17, and in the vagus nerve in 12/16 cases. In addition to the thoracic lateral horns, a high number of αSN lesions was also found in non‐autonomic spinal cord nuclei. Considering supraspinal structures our cases corresponded roughly to the recently described sequential order of αSN involvement in PD. Our study indicates, however, that the autonomic nuclei of the spinal cord and the PANS belong to the most constantly and earliest affected regions next to medullary structures and the olfactory nerves. A larger cohort of ILBD cases will be needed to pinpoint the precise induction site of αSN pathology among these structures.</div></front></TEI><affiliations><list><country><li>Suisse</li></country></list><tree><country name="Suisse"><noRegion><name sortKey="Bloch, A" sort="Bloch, A" uniqKey="Bloch A" first="A." last="Bloch">A. Bloch</name></noRegion><name sortKey="Adams, H" sort="Adams, H" uniqKey="Adams H" first="H." last="Adams">H. Adams</name><name sortKey="Bissig, H" sort="Bissig, H" uniqKey="Bissig H" first="H." last="Bissig">H. Bissig</name><name sortKey="Probst, A" sort="Probst, A" uniqKey="Probst A" first="A." last="Probst">A. Probst</name><name sortKey="Tolnay, M" sort="Tolnay, M" uniqKey="Tolnay M" first="M." last="Tolnay">M. Tolnay</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001158 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001158 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:723ADF43379CF2E95E18D5B6A936512CAF5E10F6
|texte= α‐Synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects
}}
| This area was generated with Dilib version V0.6.23. |  |